Determination of Gallic Acid in Rat Plasma by LC-MS-MS

被引：10
|
作者：
Song, Rui [1 ,2 ]
Xu, Lei [1 ,2 ]
Zhang, Zunjian [1 ,2 ]
Tian, Yuan [1 ,2 ]
Xu, Fengguo [1 ,2 ]
Dong, Haijuan [1 ,2 ]
机构：
[1] China Pharmaceut Univ, Key Lab Drug Qual Control & Pharmacovigilance, Minist Educ, Nanjing 210009, Peoples R China
[2] China Pharmaceut Univ, Ctr Instrumental Anal, Nanjing 210009, Peoples R China
来源：
CHROMATOGRAPHIA | 2010年 / 71卷 / 11-12期
关键词：
Column liquid chromatography; Tandem mass spectrometry; Gallic acid; Rhubarb; Pharmacokinetics; TANNIC-ACID; DAMAGE;
D O I：
10.1365/s10337-010-1565-2
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Liquid chromatography-electrospray ionization tandem mass spectrometry has been used for rapid, selective, and sensitive quantitative analysis of gallic acid in rat plasma. Sample pretreatment involved a one-step extraction using ethyl acetate with protocatechic acid as internal standard. Separation was on a C(18) column using an isocratic mobile phase, consisting of methanol-0.1% aqueous formic acid (40:60, v/v) at 0.2 mL min(-1). The stability of gallic acid was evaluated in acidified and non-acidified plasma. The method was validated then successfully applied to a pharmacokinetic study in rats after oral administration of rhubarb extract.
引用
收藏
页码：1107 / 1111
页数：5
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