Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration

被引：14

作者：

Daly, Conor ^{[1
]}

Ward, Rebecca ^{[1
]}

Reynolds, Alison L. ^{[2
]}

Galvin, Orla ^{[1
,3
]}

Collery, Ross F. ^{[4
]}

Kennedy, Breandan N. ^{[1
]}

机构：

[1] Univ Coll Dublin, Sch Biomol & Biomed Sci, Belfield, Ireland

[2] Univ Coll Dublin, Sch Vet Med, Belfield, Ireland

[3] RenaSci Ltd, BioCity, Nottingham, England

[4] Med Coll Wisconsin, Inst Eye, Dept Ophthalmol & Visual Sci, 8700 W Wisconsin Ave, Milwaukee, WI 53226 USA

来源：

RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY | 2018年 / 1074卷

关键词：

Brain-Derived Neurotrophic Factor; BDNF; Neuroprotection; Retinal degeneration; Photoreceptor; GANGLION-CELLS; RETINITIS-PIGMENTOSA; VISUAL FUNCTION; GENE-TRANSFER; TRKB PROTEIN; IN-VIVO; BDNF; EXPRESSION; SURVIVAL; LIGHT;

D O I：

10.1007/978-3-319-75402-4_57

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This review discusses the therapeutic potential of brain-derived neurotrophic factor (BDNF) for retinal degeneration. BDNF, nerve growth factor (NGF), neurotrophin 3 (NT-3) and NT-4/NT-5 belong to the neurotrophin family. These neuronal modulators activate a common receptor and a specific tropomyosin-related kinase (Trk) receptor. BDNF was identified as a photoreceptor protectant in models of retinal degeneration as early as 1992. However, development of effective therapeutics that exploit this pathway has been difficult due to challenges in sustaining therapeutic levels in the retina.

引用

页码：465 / 471

页数：7

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