Micellar and solubility properties of drug tetracaine-hydrochloride from thermal conductivity measurements

被引：2

作者：

Zelmat, C. ^{[1
]}

Fergoug, T. ^{[1
]}

Azayez, M. ^{[1
]}

Meddah, N. ^{[1
]}

Chater, F. ^{[1
]}

Boudjoras, H. ^{[1
]}

Bouhadda, Y. ^{[1
]}

机构：

[1] Univ Mascara, Lab Chim Phys Macromol & Interfaces Biol, Mascara 29000, Algeria

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2019年 / 293卷

关键词：

Conductivity; Tetracaine-hydrochloride; Krafft temperature; Phase diagram; Standard Gibbs free energy; Standard enthalpy; Standard entropy; Surface tension; LOCAL-ANESTHETIC TETRACAINE; ENTHALPY-ENTROPY COMPENSATION; TEMPERATURE; SURFACTANTS; MICELLIZATION; ENCAPSULATION;

D O I：

10.1016/j.molliq.2019.111572

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Solubility and micelle formation of tetracaine-hydrochloride (TC,HCl) in aqueous solution has been studied by thermal conductivity. From thermal variations of the specific conductivity, parameters such as the critical micelle concentration, cmc, Krafft temperature, T-K, and the variation of solubility with temperature were determined. The cmc's data analysis according to the mass action model has enabled to determine free energies of adsorption and of the micelles formation. A partial phase diagram of TC,HCl in water was also deduced and the micellization process discussed in light of enthalpy and entropy contributions. (C) 2019 Elsevier B.V. All rights reserved.

引用

页数：6

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