Multiple regions within 8q24 independently affect risk for prostate cancer

被引：508

作者：

Haiman, Christopher A.

Patterson, Nick

Freedman, Matthew L.

Myers, Simon R.

Pike, Malcolm C.

Waliszewska, Alicja

Neubauer, Julie

Tandon, Arti

Schirmer, Christine

McDonald, Gavin J.

Greenway, Steven C.

Stram, Daniel O.

Le Marchand, Loic

Kolonel, Laurence N.

Frasco, Melissa

Wong, David

Pooler, Loreall C.

Ardlie, Kristin

Oakley-Girvan, Ingrid

Whittemore, Alice S.

Cooney, Kathleen A.

John, Esther M.

Ingles, Sue A.

Altshuler, David

Henderson, Brian E.

Reich, David ^{[1
]}

机构：

[1] Harvard Univ, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA

[2] MIT, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA

[3] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA

[4] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[6] Brigham & Womens Hosp, Ctr Neurol Dis, Lab Mol Immunol, Boston, MA 02115 USA

[7] Univ Hawaii, Canc Res Ctr, Program Epidemiol, Honolulu, HI 96813 USA

[8] Genom Collaborat, Cambridge, MA 02139 USA

[9] No Calif Canc Ctr, Fremont, CA 94538 USA

[10] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA

[11] Univ Michigan, Dept Med, Ann Arbor, MI 48109 USA

[12] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA

[13] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[14] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[15] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

[16] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

来源：

NATURE GENETICS | 2007年 / 39卷 / 05期

关键词：

D O I：

10.1038/ng2015

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer from five populations. We identified seven risk variants, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 x 10(-19) for the strongest association, and P < 1.5 x 10(-4) for five of the variants, after controlling for each of the others). The variants define common genotypes that span a more than fivefold range of susceptibility to cancer in some populations. None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein.

引用

页码：638 / 644

页数：7

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