Rapid and General Protocol towards Catalyst-Free Friedel-Crafts C-Alkylation of Indoles in Water Assisted by Microwave Irradiation

被引：23
|
作者：
De Rosa, Margherita [1 ]
Soriente, Annunziata [1 ]
机构：
[1] Univ Salerno, Dipartimento Chim, I-84084 Fisciano, SA, Italy
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 06期
关键词：
Indoles; Friedel-Crafts reaction; Microwave irradiation; Superheated water; Synthetic methods; Nitrogen heterocycles; Microwave chemistry; Alkylation; ORGANIC-SYNTHESIS; NUCLEOPHILIC SUBSTITUTIONS; CHEMICAL-REACTIONS; ENERGY EFFICIENCY; ALCOHOLS; CHEMISTRY; ALPHA;
D O I：
10.1002/ejoc.200901333
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and simplified protocol for uncatalyzed Friedel-Crafts alkylation of indoles rising microwave irradiation in water is described. A series of functionalized indole derivatives has been synthesized in very short times with moderate to good yields. The combination of microwave irradiation and superheated water offers significant advantages over conventional methods, such as higher selectivities, simplicity, shorter reaction times, and no need for a catalyst,
引用
收藏
页码：1029 / 1032
页数：4
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