Novel activators of the tumour suppressor p53

被引：2

作者：

Sunder-Plassmann, N ^{[1
]}

Giannis, A ^{[1
]}

机构：

[1] Univ Leipzig, Inst Organ Chem, D-04103 Leipzig, Germany

来源：

CHEMBIOCHEM | 2004年 / 5卷 / 12期

关键词：

antitumor agents; drug design; inhibitors; proteins;

D O I：

10.1002/cbic.200400194

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A paramount role in carcinogenesis is played by the tumour-suppressor protein p53. In the case of DNA damage, it leads to cell-cycle arrest or apoptosis. p53 activity is often reduced due to the overexpression of its main regulator, the Mdm2 protein. The discovery of small molecules, such as 1, that are able to inhibit the interaction between p53 and Mdm2 opens up new possibilities for the therapy of malignant diseases.

引用

页码：1635 / 1637

页数：3

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