Deep-tissue imaging of intramolecular fluorescence resonance energy-transfer parameters

被引：18

作者：

Gaind, Vaibhav ^{[1
]}

Kularatne, Sumith ^{[2
]}

Low, Philip S. ^{[2
]}

Webb, Kevin J. ^{[1
]}

机构：

[1] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA

[2] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

OPTICS LETTERS | 2010年 / 35卷 / 09期

基金：

美国国家科学基金会;

关键词：

PROTEIN INTERACTIONS; FRET;

D O I：

10.1364/OL.35.001314

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate the in vivo reconstruction of all fluorescence resonance energy transfer (FRET) parameters, including the nanometer donor-acceptor distance, in a mouse. The FRET chemical targets cancer cells, and on internalization, the acceptor is released, in lieu of a targeted anticancer drug in chemotherapy. Our method provides a new vehicle for studying disease by imaging FRET parameters in deep tissue. (C) 2010 Optical Society of America

引用

页码：1314 / 1316

页数：3

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