Intravitreal bevacizurnab (Avastin) injection in ocular ischemic syndrome

PURPOSE: To determine whether bevacizumab may im- prove anatomic and visual outcomes in patients with ocular ischemic syndrome (OIS). DESIGN: Interventional case reports. METHODS: Two patients with OIS presenting with unilat- eral ocular pain, iris neovascularization, and macular edema. Intravitreal injection of bevacizumab (1.25 mg). The main outcome measures were postinjection bestcorrected visual acuity (BCVA), intraocular pressure (lop), angiographic findings, and optical coherence tomography (OCT) findings and complications. RESULTS: One week after treatment, both patients dem- onstrated regression of the iris neovascularization and improvement of the macular edema, with no changes in BCVA and IOP. One eye was reinjected at four months. After three and seven months, no significant or systemic adverse events were observed, and no signs of new iris neovascularization were present. CONCLUSIONS: Intravitreal bevacizumab may be useful for the treatment of eyes with iris neovascularization and macular edema secondary to OIS.