Vecuronium-induced neuromuscular block during xenon or sevoflurane anaesthesia in humans

被引：15
|
作者：
Nakata, Y [1 ]
Goto, T [1 ]
Morita, S [1 ]
机构：
[1] Teikyo Univ, Sch Med, Ichihara Hosp, Dept Anaesthesia, Chiba 29901, Japan
来源：
BRITISH JOURNAL OF ANAESTHESIA | 1998年 / 80卷 / 02期
关键词：
anaesthetics gases; xenon; anaesthetics volatile; sevoflurane; monitoring; neuromuscular block; vecuronium; measurement of response;
D O I：
10.1093/bja/80.2.238
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Twitch response using accelerometry and plasma concentrations of vecuronium and its metabolite were studied in 27 surgical patients during xenon or sevoflurane anaesthesia after administration of vecuronium 0.05 mg kg(-1). Anaesthesia was maintained using oxygen-xenon (MAC=71%) or oxygen-sevoflurane (MAC=2%) at an end-tidal concentration equal to 0.8 MAC (i.e. 57% xenon and 1.6% sevoflurane). Mean time from administration of vecuronium to 25% recovery of the first twitch of the train-of-four response was significantly shorter in the xenon group than in the sevoflurane group (12.9 (so 2.5) min vs 19.4 (6.0) min, respectively). Plasma concentrations of vecuronium at 25% recovery were significantly higher during xenon than during sevoflurane anaesthesia (187 (49) ng ml(-1) vs 136 (40) ng ml(-1), respectively), while those of 3-desacetylvecuronium were similar in both groups.
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收藏
页码：238 / 240
页数：3
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