Multicomponent synthesis of highly substituted 2-pyridones

被引：23
|
作者：
Neo, Ana G.
Maria Carrillo, Rosa
Barriga, Susana
Moman, Edelmiro
Marcaccini, Stefano
Marcos, Carlos F. [1 ]
机构：
[1] Univ Extremadura, Fac Vet, Dept Quim Organ, Lab Quim Organ & Bioorgan,LOBO, Caceres 10071, Spain
[2] Royal Coll Surgeons Ireland, Ctr Synth & Chem Biol, Dept Pharmaceut & Med Chem, Dublin 2, Ireland
[3] Univ Florence, Dipartimento Chim Organ Ugo Schiff, I-50019 Sesto Fiorentino, FI, Italy
来源：
SYNLETT | 2007年 / 02期
关键词：
cyclisations; drugs; heterocycles; multicomponent reactions; pyridines;
D O I：
10.1055/s-2007-967992
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel synthesis of polyfunctionalised pyridones, structurally related to cardiotonic agent milrinone is described. The procedure consists of an Ugi four-component reaction of 3-formyl-chromones, followed by a base-promoted ring-opening/ring-closing process. Variation of three of the four components in the Ugi reaction allows access to the final products with a combinatorial distribution of substituents.
引用
收藏
页码：327 / 329
页数：3
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