Physiological and pathological implications of laminins:: From the gene to the protein

被引：12

作者：

Paez, Maria-Carolina

Gonzalez, Maria-Julieta

Serrano, Norma C.

Shoenfeld, Yehuda

Anaya, Juan-Manuel ^{[1
]}

机构：

[1] Corp Invest Biol, Cellular Biol & Immunogenet Unit, Medellin, Colombia

[2] UNAB, Sch Med, Biomed Res Ctr, Bucaramanga, Colombia

[3] Univ Chile, Inst Biomed Sci, Fac Med, Cell & Mol Biol Program, Santiago, Chile

[4] Chaim Sheba Med Ctr, Dept Med B, IL-52621 Tel Hashomer, Israel

[5] Chaim Sheba Med Ctr, Ctr Autoimmune Dis, IL-52621 Tel Hashomer, Israel

[6] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[7] Univ Nacl Rosario, Medellin, Colombia

来源：

AUTOIMMUNITY | 2007年 / 40卷 / 02期

关键词：

laminin; extracellular matrix; basal lamina; systemic lupus erythematosus; Sjogren's syndrom;

D O I：

10.1080/08916930600911519

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjogren's syndrome (SS) are also discussed.

引用

页码：83 / 94

页数：12

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