Development of novel mannitol blended PVA hydrogel membrane and its anticancer and antimicrobial drug delivery potential for wound dressing applications

The prepared poly(vinyl) alcohol/mannitol (PM) hydrogel was examined to assess its drug delivery activity against MCF-7 cells and pathogenic strain. The structure of PM hydrogel was concluded by the physical interaction of mannitol with poly(vinyl) alcohol (PVA) matrix using FTIR. The PM hydrogel exhibited two-step decomposition processes with the remained % weight residue of 8% above 550 degrees C. The water uptake and water retention properties of PM hydrogel were understood by carrying out the swelling index and moisture loss analysis. The PM hydrogel was non-hemolytic to red blood cells due to its low hemolysis percentage of 3.09. PM hydrogel had not induced any high level of thrombus formation. The pathogenic strains of S. aureus and P. aeruginosa were effectively inhibited by the Cephalosporin-loaded and Streptomycin-loaded PM hydrogels respectively. The anticancer activity of curcumin-loaded PM hydrogel was inspected against MCF-7 cells (breast cancer cell line). The drug delivery activity of PVA hydrogel was carried out at three different pHs.