A review of the genus Sapotes Casey (Curculionidae: Entiminae) is presented. Three new species from the central and southern Chihuahuan desert region of Mexico are described: Sapotes caseyi new species, Sapotes setosus new species, and Sapotes sordidus new species. A key is presented to identify all five species of the genus, along with observations on the geographical distribution and host associations of the newly described species.