Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease

被引：52
|
作者：
Ramajayam, R. [1 ]
Tan, Kian-Pin [2 ]
Liu, Hun-Ge [2 ]
Liang, Po-Huang [1 ,2 ]
机构：
[1] Acad Sinica, Inst Biol Chem, Taipei 11529, Taiwan
[2] Natl Taiwan Univ, Inst Biochem Sci, Taipei 106, Taiwan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 12期
关键词：
SARS-CoV; Pyrimidines; RESPIRATORY SYNDROME CORONAVIRUS; MAIN PROTEASE; IDENTIFICATION; DESIGN; DERIVATIVES; CINANSERIN; ANALOGS;
D O I：
10.1016/j.bmcl.2010.04.118
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 2-(benzylthio)-6-oxo-4-phenyl-1,6-dihydropyrimidine as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Two candidates had encouraging results for the development of new anti-SARS compounds. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3569 / 3572
页数：4
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