RTX-321, an allogeneic artificial antigen presenting red cell therapeutic, expressing MHC I-Peptide, 41BBL and IL12, promotes antigen-specific T cell expansion and anti-tumor activity in HPV16+tumors

被引：0
|
作者：
Zhang, Xuqing [1 ]
Chen, Tiffany [1 ]
机构：
[1] Rubius Therapeut, Cambridge, MA USA
来源：
JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2019年 / 7卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
P233
引用
收藏
页数：1
相关论文
共 3 条
  • [1] An Engineered Allogeneic Artificial Antigen Presenting Red Cell Therapeutic, Rtx-321, for Hpv16+Associated Cancers Promotes Antigen-Specific T Cell Activation & Expansion
    Dastagir, Shamael R.
    Zhang, Xuqing
    Lee, Albert
    Lyford, Timothy J.
    Mellen, Jennifer M.
    Schmidt, Andrea
    Gribble, Mary
    Moore, Chris
    Wickham, Thomas J.
    Chen, Tiffany F.
    MOLECULAR THERAPY, 2020, 28 (04) : 147 - 147
  • [2] RTX-321, an allogeneic red blood cell-based artificial antigen presenting cell, expressing MHC I-peptide, 4-1BBL and IL-12, engages primary human HPV-specific T cells and boosts other general immune responses.
    Luo, Mengyao
    Dastagir, Shamael S.
    Zhang, Xuqing
    Schmidt, Andrea
    Marques, Beatriz
    Lyford, Timothy J.
    Blanco, Billy
    Turka, Laurence A.
    Wickham, Thomas J.
    Chen, Tiffany F.
    CANCER IMMUNOLOGY RESEARCH, 2021, 9 (02)
  • [3] A phase 1 study of RTX-321, an engineered red blood cell as an artificial antigen-presenting cell expressing HLA-A*02 with the HPV-16 E7 peptide and 4-1BB ligand with membrane-bound IL-12 for the treatment of HPV 16-positive cancers.
    Bendell, Johanna C.
    Spira, Alexander I.
    Eskander, Ramez Nassef
    Cohen, Ezra E. W.
    Kuesters, Geoffrey
    Plescia, Christopher
    Campbell, Karen
    Chen, Tiffany
    Hamid, Omid
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
1