The epidemiology of tuberculosis in the rural Balimo region of Papua New Guinea

被引:8
|
作者
Diefenbach-Elstob, Tanya [1 ,2 ]
Graves, Patricia [1 ]
Dowi, Robert [3 ]
Gula, Bisato [3 ]
Plummer, David [1 ]
McBryde, Emma [2 ]
Pelowa, Daniel [3 ]
Siba, Peter [4 ]
Pomat, William [4 ]
Warner, Jeffrey [1 ,2 ]
机构
[1] James Cook Univ, Coll Publ Hlth Med & Vet Sci, Townsville, Qld 4811, Australia
[2] James Cook Univ, Australian Inst Trop Hlth & Med, Townsville, Qld, Australia
[3] Balimo Dist Hosp, Balimo, Western Provinc, Papua N Guinea
[4] Papua New Guinea Inst Med Res, Goroka, Eastern Highlan, Papua N Guinea
关键词
pulmonary tuberculosis; extrapulmonary tuberculosis; epidemiology; Papua New Guinea; drug resistance; tuberculose pulmonaire; tuberculose extrapulmonaire; epidemiologie; PNG; resistance aux medicaments; MULTIDRUG-RESISTANT TUBERCULOSIS; WESTERN PROVINCE; REMOTE REGION; MELIOIDOSIS; COMMUNITY; OUTBREAK; CHILDREN; BURDEN;
D O I
10.1111/tmi.13118
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
ObjectivePapua New Guinea (PNG) has an emerging tuberculosis (TB) epidemic which has become a national public health priority. In Western Province, there are few data about TB outside Daru and the South Fly District. This study describes the epidemiology of TB diagnosed at Balimo District Hospital (BDH) in the Middle Fly District of Western Province, PNG. MethodsAll patients (n = 1614) diagnosed with TB at BDH from April 2013 to February 2017 were recorded. Incidence of reported new cases was calculated for the combined Balimo Urban and Gogodala Rural local level government areas. Analyses investigated patient demographic and clinical information, differences between pulmonary and extrapulmonary TB patients, and predictors of treatment failure. ResultsThe average case notification rate (2014-2016) was 727 TB cases per 100 000 people per year. One-quarter of TB cases were in children, and 77.1% of all cases had an extrapulmonary TB diagnosis. There was a 1:1.1 ratio of female to male TB cases. When comparing pulmonary and extrapulmonary TB patients, extrapulmonary TB was more likely in those aged up to 14 years and over 54 years. Extrapulmonary TB was more likely in new patients, and pulmonary TB more likely in previously treated patients. Residence in rural regions was associated with treatment failure. ConclusionThere is a high burden of TB in the Balimo region, including a very high proportion of extrapulmonary TB. These factors emphasise the importance of BDH as the primary hospital for TB cases in the Balimo region and the Middle Fly District, and the need for resources and staff to manage both drug-susceptible and drug-resistant TB cases. ObjectifLa Papouasie-Nouvelle-Guinee (PNG) a une epidemie de tuberculose (TB) emergente qui est devenue une priorite nationale de sante publique. Dans la province de l'Ouest, il y a peu de donnees sur la TB en dehors de Daru et du district de South Fly. Cette etude decrit l'epidemiologie de la TB diagnostiquee a l'Hopital de District a Balimo (BDH) dans le district de Middle Fly de la province de l'Ouest, en PNG. MethodesTous les patients (n=1614) ayant recu un diagnostic de TB a BDH entre avril 2013 et fevrier 2017 ont ete enregistres. L'incidence des nouveaux cas rapportes a ete calculee pour les zones gouvernementales combinees de Balimo Urban et de Gogodala Rural. Les analyses ont porte sur les donnees demographiques et cliniques des patients, les differences entre les patients a TB pulmonaire et extrapulmonaire et les facteurs predictifs d'echec du traitement. ResultatsLe taux moyen de notification des cas (2014-2016) etait de 727 cas de TB par 100.000 personnes par an. Un quart des cas de TB concernait des enfants et 77.1% de tous les cas avaient un diagnostic de TB extrapulmonaire. Il y avait un rapport de 1:1.1 femmes/hommes dans les cas de TB. En comparant les cas pulmonaires et extrapulmonaires, la TB extrapulmonaire etait plus probable chez les patients ages de moins de 14 ans et ceux de plus de 54 ans. La TB extrapulmonaire etait plus probable chez les nouveaux patients et la TB pulmonaire plus probable chez les patients precedemment traites. La residence dans les regions rurales etait associee a un echec du traitement. ConclusionLa charge de TB dans la region de Balimo est elevee, y compris une tres forte proportion de TB extrapulmonaire. Ces facteurs soulignent l'importance de BDH en tant qu'hopital primaire pour les cas de TB dans la region de Balimo et le district de Middle Fly, et le besoin de ressources et de personnel pour gerer a la fois les cas de TB sensible et resistante.
引用
收藏
页码:1022 / 1032
页数:11
相关论文
共 50 条
  • [1] The epidemiology of melioidosis in the Balimo region of Papua New Guinea
    Warner, J. M.
    Pelowa, D. B.
    Gal, D.
    Rai, G.
    Mayo, M.
    Currie, B. J.
    Govan, B.
    Skerratt, L. F.
    Hirst, R. G.
    [J]. EPIDEMIOLOGY AND INFECTION, 2008, 136 (07): : 965 - 971
  • [2] Molecular Evidence of Drug-Resistant Tuberculosis in the Balimo Region of Papua New Guinea
    Diefenbach-Elstob, Tanya
    Guernier, Vanina
    Burgess, Graham
    Pelowa, Daniel
    Dowi, Robert
    Gula, Bisato
    Puri, Munish
    Pomat, William
    McBryde, Emma
    Plummer, David
    Rush, Catherine
    Warner, Jeffrey
    [J]. TROPICAL MEDICINE AND INFECTIOUS DISEASE, 2019, 4 (01)
  • [3] Molecular diagnosis of suspected tuberculosis from archived smear slides from the Balimo region, Papua New Guinea
    Guernier, Vanina
    Diefenbach-Elstob, Tanya
    Pelowa, Daniel
    Pollard, Sandra
    Burgess, Graham
    McBryde, Emma S.
    Warner, Jeffrey
    [J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2018, 67 : 75 - 81
  • [4] Spatial distribution of tuberculosis in a rural region of Western Province, Papua New Guinea
    Diefenbach-Elstob, Tanya
    Guernier-Cambert, Vanina
    Gula, Bisato
    Dowi, Robert
    Pelowa, Daniel
    Pomat, William
    Rush, Catherine
    Plummer, David
    McBryde, Emma
    Warner, Jeffrey
    [J]. WESTERN PACIFIC SURVEILLANCE AND RESPONSE, 2019, 10 (04)
  • [6] The epidemiology of malaria in Papua New Guinea
    Müller, I
    Bockarie, M
    Alpers, M
    Smith, T
    [J]. TRENDS IN PARASITOLOGY, 2003, 19 (06) : 253 - 259
  • [7] Seroepidemiology of Strongyloides spp. Infection in Balimo, Western Province, Papua New Guinea
    Scott, Jessica
    Emeto, Theophilus I.
    Melrose, Wayne
    Warner, Jeffrey
    Rush, Catherine
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2023, 108 (02): : 346 - 352
  • [8] Practising in rural Papua New Guinea
    Poka, H
    [J]. MEDICAL JOURNAL OF AUSTRALIA, 2004, 181 (11-12) : 609 - 609
  • [9] The social determinants of tuberculosis treatment adherence in a remote region of Papua New Guinea
    Tanya Diefenbach-Elstob
    David Plummer
    Robert Dowi
    Sinba Wamagi
    Bisato Gula
    Keyanato Siwaeya
    Daniel Pelowa
    Peter Siba
    Jeffrey Warner
    [J]. BMC Public Health, 17
  • [10] The social determinants of tuberculosis treatment adherence in a remote region of Papua New Guinea
    Diefenbach-Elstob, Tanya
    Plummer, David
    Dowi, Robert
    Wamagi, Sinba
    Gula, Bisato
    Siwaeya, Keyanato
    Pelowa, Daniel
    Siba, Peter
    Warner, Jeffrey
    [J]. BMC PUBLIC HEALTH, 2017, 17