Cysteine biosynthesis in the Archaea:: Methanosarcina thermophila utilizes O-acetylserine sulfhydrylase

被引：11
|
作者：
Borup, B
Ferry, JG [1 ]
机构：
[1] Penn State Univ, Dept Biochem & Mol Biol, S Frear Lab 205, University Pk, PA 16802 USA
[2] Penn State Univ, Dept Chem, University Pk, PA 16802 USA
来源：
FEMS MICROBIOLOGY LETTERS | 2000年 / 189卷 / 02期
基金：
美国国家航空航天局;
关键词：
CysK; CysE; cysteine biosynthesis; sulfur metabolism; NifS; archaeon;
D O I：
10.1016/S0378-1097(00)00284-6
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Two pathways for cysteine biosynthesis are known in nature; however, it is not known which, if either, the Archaea utilize. Enzyme activities in extracts of Methanosarcina thermophila grown with combinations of cysteine and sulfide as sulfur sources indicated that this archaeon utilizes the pathway found in the Bacteria domain. The genes encoding serine transacetylase and O-acetylserine sulfhydrylase (cysE and cysK) are adjacent on the chromosome of M. thermophila and possibly form an operon. When M. thermophila is grown with cysteine as the sole sulfur source, O-acetylserine sulfhydrylase activity is maximally expressed suggesting alternative roles for this enzyme apart from cysteine biosynthesis. (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：205 / 210
页数：6
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