Flow and Particle Dispersion in a Pulmonary Alveolus-Part II: Effect of Gravity on Particle Transport

The acinar region of the human lung comprises about 300 X 106 alveoli, which are responsible for gas exchange between the lung and the blood As discussed in Part 1 (Chhabra and Prasad. "Flow and Particle Dispersion in a Pulmonary Alveolus Part 1 Velocity Measurements and Convective Particle Transport." ASME J Biomech Eng, 132. p 051009), the deposition of aerosols in the acinar region can either be detrimental to gas exchange (as in the case of harmful particulate matter) or beneficial (as in the case of inhalable pharmaceuticals) We measured the flow field inside an in-vitro model of a single alveolus mounted on a bronchiole and calculated the transport and deposition of massless particles in Part I This paper focuses on the transport and deposition of finite-sized particles ranging from 0.25 mu m to 4 mu m under the combined influence of flow-Induced advection (computed from velocity maps obtained by particle image velocimetry) and gravitational settling Particles were introduced during the first inhalation cycle and their trajectories and deposition statistics were calculated for subsequent cycles for three different particle sizes (0 25 mu m, 1 mu m, and 4 mu m) and three alveolar orientations The key outcome of the study is that particles 25 pin follow the fluid streamlines quite closely, whereas midsize particles (d(p) = 1 mu m) deviate to some extent from streamlines and exhibit complex trajectories The motion of large particles >= 4 mu m is dominated by gravitational settling and shows little effect of fluid advection Additionally. small and midsize particles deposit at about two-thirds height in the alveolus irrespective of the gravitational orientation whereas the deposition of large particles is governed primarily by the orientation of the gravity vector [DOI 10.1115/1.4001113]