Exploitation of 2-Hydroxyglutarate-Mediated Deficiency in Homologous Recombination with PARP Inhibition to Achieve Radiosensitization in IDH-Mutant Tumors

被引：0
|
作者：
Wild, A. [1 ]
Wang, Y. [1 ]
Wu, W. [1 ]
Haddock, S. L. [1 ]
Chan, T. A. [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA
来源：
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2018年 / 102卷 / 03期
关键词：
D O I：
10.1016/j.ijrobp.2018.06.292
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
239
引用
收藏
页码：S117 / S117
页数：1
相关论文
共 10 条
  • [1] IDH-Mutant Brain Tumors Hit the Achilles' Heel of Macrophages with R-2-Hydroxyglutarate
    van Dierendonck, Xanthe A. M. H.
    de Goede, Kyra E.
    Van den Bossche, Jan
    TRENDS IN CANCER, 2021, 7 (08): : 666 - 667
  • [2] Prediction of homologous recombination deficiency identifies colorectal tumors sensitive to PARP inhibition
    Corti, Giorgio
    Buzo, Kristi
    Berrino, Enrico
    Miotto, Martina
    Aquilano, Maria Costanza
    Lentini, Marilena
    Bellomo, Sara Erika
    Lorenzato, Annalisa
    Bartolini, Alice
    Mauri, Gianluca
    Lazzari, Luca
    Russo, Mariangela
    Di Nicolantonio, Federica
    Siena, Salvatore
    Marsoni, Silvia
    Marchio, Caterina
    Bardelli, Alberto
    Arena, Sabrina
    NPJ PRECISION ONCOLOGY, 2024, 8 (01)
  • [3] 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
    Sulkowski, Parker L.
    Corso, Christopher D.
    Robinson, Nathaniel D.
    Scanlon, Susan E.
    Purshouse, Karin R.
    Bai, Hanwen
    Liu, Yanfeng
    Sundaram, Ranjini K.
    Hegan, Denise C.
    Fons, Nathan R.
    Breuer, Gregory A.
    Song, Yuanbin
    Mishra-Gorur, Ketu
    De Feyter, Henk M.
    de Graaf, Robin A.
    Surovtseva, Yulia V.
    Kachman, Maureen
    Halene, Stephanie
    Gunel, Murat
    Glazer, Peter M.
    Bindra, Ranjit S.
    SCIENCE TRANSLATIONAL MEDICINE, 2017, 9 (375)
  • [4] 2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas
    Viswanath, Pavithra
    Radoul, Marina
    Luis Izquierdo-Garcia, Jose
    Ong, Wei Qiang
    Luchman, Hema Artee
    Cairncross, J. Gregory
    Huang, Bo
    Pieper, Russell O.
    Phillips, Joanna J.
    Ronen, Sabrina M.
    CANCER RESEARCH, 2018, 78 (09) : 2290 - 2304
  • [5] hMOB2 deficiency impairs homologous recombination-mediated DNA repair and sensitises cancer cells to PARP inhibitors
    Gundogdu, Ramazan
    Erdogan, M. Kadir
    Ditsiou, Angeliki
    Spanswick, Victoria
    Garcia-Gomez, Juan Jose
    Hartley, John A.
    Esashi, Fumiko
    Hergovich, Alexander
    Gomez, Valenti
    CELLULAR SIGNALLING, 2021, 87
  • [6] AXL inhibition prevents RPA2/CHK1-mediated homologous recombination to increase PARP inhibitor sensitivity in hepatocellular carcinoma
    Li, Kai-Min
    Deng, Li-gong
    Xue, Li-Jun
    Tan, Chang
    Yao, Shu-Kun
    HELIYON, 2024, 10 (17)
  • [7] LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair
    Chen, Lifeng
    Hou, Jing
    Zeng, Xiangyu
    Guo, Qiang
    Deng, Min
    Kloeber, Jake A.
    Tu, Xinyi
    Zhao, Fei
    Wu, Zheming
    Huang, Jinzhou
    Luo, Kuntian
    Kim, Wootae
    Lou, Zhenkun
    CLINICAL AND TRANSLATIONAL MEDICINE, 2021, 11 (03):
  • [8] SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors
    Xiaomin Wang
    Ziqi Chen
    Jun Xu
    Shuai Tang
    Nan An
    Lei Jiang
    Yixiang Zhang
    Shaoying Zhang
    Qingli Zhang
    Yanyan Shen
    Shijie Chen
    Xiaojing Lan
    Ting Wang
    Linhui Zhai
    Siyuwei Cao
    Siqi Guo
    Yingluo Liu
    Aiwei Bi
    Yuehong Chen
    Xiameng Gai
    Yichen Duan
    Ying Zheng
    Yixian Fu
    Yize Li
    Liang Yuan
    Linjiang Tong
    Kun Mo
    Mingcheng Wang
    Shu-Hai Lin
    Minjia Tan
    Cheng Luo
    Yi Chen
    Jia Liu
    Qiansen Zhang
    Leping Li
    Min Huang
    Cell Research, 2022, 32 : 638 - 658
  • [9] SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors
    Wang, Xiaomin
    Chen, Ziqi
    Xu, Jun
    Tang, Shuai
    An, Nan
    Jiang, Lei
    Zhang, Yixiang
    Zhang, Shaoying
    Zhang, Qingli
    Shen, Yanyan
    Chen, Shijie
    Lan, Xiaojing
    Wang, Ting
    Zhai, Linhui
    Cao, Siyuwei
    Guo, Siqi
    Liu, Yingluo
    Bi, Aiwei
    Chen, Yuehong
    Gai, Xiameng
    Duan, Yichen
    Zheng, Ying
    Fu, Yixian
    Li, Yize
    Yuan, Liang
    Tong, Linjiang
    Mo, Kun
    Wang, Mingcheng
    Lin, Shu-Hai
    Tan, Minjia
    Luo, Cheng
    Chen, Yi
    Liu, Jia
    Zhang, Qiansen
    Li, Leping
    Huang, Min
    CELL RESEARCH, 2022, 32 (07) : 638 - 658
  • [10] Genomic analysis from the talazoparib beyond BRCA clinical trial: Homologous recombination (HR) deficiency scores, loss-of-heterozygosity and mutations in non-BRCA1/2 mutant tumors with other HR mutations
    Gruber, Joshua J.
    Afghahi, Anosheh
    Hatton, Alyssa
    Gross, Wyatt
    Foran, Jessica
    McMillan, Alex
    Ford, James M.
    Telli, Melinda L.
    CANCER RESEARCH, 2021, 81 (04)
1