Caesarean delivery is associated with increased blood pressure in young adult offspring

被引:5
|
作者
Rerkasem, Amaraporn [1 ]
Maessen, Sarah E. [2 ]
Wongthanee, Antika [3 ]
Pruenglampoo, Sakda [1 ]
Mangklabruks, Ampica [3 ]
Sripan, Patumrat [1 ]
Derraik, Jose G. B. [1 ,2 ,4 ,5 ]
Rerkasem, Kittipan [1 ,6 ]
机构
[1] Chiang Mai Univ, NCD Ctr Excellence, Res Inst Hlth Sci, Chiang Mai, Thailand
[2] Univ Auckland, Liggins Inst, Auckland, New Zealand
[3] Chiang Mai Univ, Fac Med, Dept Internal Med, Chiang Mai, Thailand
[4] Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden
[5] Zhejiang Univ, Childrens Hosp, Dept Endocrinol, Sch Med, Hangzhou, Peoples R China
[6] Chiang Mai Univ, Fac Med, Dept Surg, Chiang Mai, Thailand
关键词
GUT MICROBIOTA; OVERWEIGHT; SECTION; OBESITY; RISK; HYPERTENSION; PREGNANCY; CHILDHOOD; BIRTH; MOTHER;
D O I
10.1038/s41598-021-89438-3
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We examined the associations between caesarean section (CS) delivery and cardiovascular risk factors in young adults in Thailand. Participants were 632 offspring from a birth cohort in Chiang Mai (Northern Thailand), born in 1989-1990 and assessed in 2010 at a mean age of 20.6 years, including 57 individuals (9.0%) born by CS and 575 born vaginally. Clinical assessments included anthropometry, blood pressure (BP), carotid intima-media thickness, and fasting blood glucose, insulin, and lipid profile. Young adults born by CS had systolic BP (SBP) 6.2 mmHg higher (p<0.001), diastolic BP 3.2 mmHg higher (p=0.029), and mean arterial pressure (MAP) 4.1 mmHg higher (p=0.003) than those born vaginally. After covariate adjustments, SBP and MAP remained 4.1 mmHg (p=0.006) and 2.9 mmHg (p=0.021) higher, respectively, in the CS group. The prevalence of abnormal SBP (i.e., pre-hypertension or hypertension) in the CS group was 2.5 times that of those born vaginally (25.0% vs 10.3%; p=0.003), with an adjusted relative risk of abnormal SBP 1.9 times higher (95% CI 1.15, 2.98; p=0.011). There were no differences in anthropometry (including obesity risk) or other metabolic parameters. In this birth cohort in Thailand, CS delivery was associated with increased blood pressure in young adulthood.
引用
收藏
页数:9
相关论文
共 50 条
  • [1] Caesarean delivery is associated with increased blood pressure in young adult offspring
    Amaraporn Rerkasem
    Sarah E. Maessen
    Antika Wongthanee
    Sakda Pruenglampoo
    Ampica Mangklabruks
    Patumrat Sripan
    José G. B. Derraik
    Kittipan Rerkasem
    [J]. Scientific Reports, 11
  • [2] Preterm Birth is Associated With Increased Blood Pressure in Young Adult Women
    Skudder-Hill, Loren
    Ahlsson, Fredrik
    Lundgren, Maria
    Cutfield, Wayne S.
    Derraik, Jose G. B.
    [J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2019, 8 (12):
  • [3] Young maternal age at delivery is associated with asthma in adult offspring
    Laerum, Birger N.
    Svanes, Cecilie
    Wentzel-Larsen, Tore
    Gulsvik, Amund
    Toren, Kjell
    Norrman, Eva
    Gislason, Thorarinn
    Janson, Christer
    Omenaas, Ernst
    [J]. RESPIRATORY MEDICINE, 2007, 101 (07) : 1431 - 1438
  • [4] Anaemia is associated with an increased risk for caesarean delivery
    Adam, Ishag
    Kheiri, Sumeya
    Sharif, Manal E.
    Ahmed, Abdel B. A.
    Rayis, Duria A.
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2019, 147 (02) : 202 - 205
  • [5] Adult rabbit offspring of mothers with secondary hypertension have increased blood pressure
    Denton, KM
    Flower, RL
    Stevenson, KM
    Anderson, WP
    [J]. HYPERTENSION, 2002, 40 (03) : 418 - 418
  • [6] Prenatal hypoxia in rats increased blood pressure and sympathetic drive of the adult offspring
    Pavel Svitok
    Lubos Molcan
    Katarina Stebelova
    Anna Vesela
    Natalia Sedlackova
    Eduard Ujhazy
    Mojmir Mach
    Michal Zeman
    [J]. Hypertension Research, 2016, 39 : 501 - 505
  • [7] Adult rabbit offspring of mothers with secondary hypertension have increased blood pressure
    Denton, KM
    Flower, RL
    Stevenson, KM
    Anderson, WP
    [J]. HYPERTENSION, 2003, 41 (03) : 634 - 639
  • [8] Prenatal hypoxia in rats increased blood pressure and sympathetic drive of the adult offspring
    Svitok, Pavel
    Molcan, Lubos
    Stebelova, Katarina
    Vesela, Anna
    Sedlackova, Natalia
    Ujhazy, Eduard
    Mach, Mojmir
    Zeman, Michal
    [J]. HYPERTENSION RESEARCH, 2016, 39 (07) : 501 - 505
  • [9] Prenatal dehydration alters renin–angiotensin system associated with angiotensin-increased blood pressure in young offspring
    Junchang Guan
    Caiping Mao
    Feichao Xu
    Chunsong Geng
    Liyan Zhu
    Aiqing Wang
    Zhice Xu
    [J]. Hypertension Research, 2009, 32 : 1104 - 1111
  • [10] Adult rabbit offspring of mothers with secondary hypertension have increased blood pressure
    Denton, KM
    Flower, RL
    Stevenson, KM
    Anderson, WP
    [J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2003, 30 (07) : A34 - A34