Pharmacodynamic evaluation of extending the administration time of meropenem using a Monte Carlo simulation

被引：68
|
作者：
Lomaestro, BM
Drusano, GL
机构：
[1] Albany Med Ctr Hosp, Albany, NY 12208 USA
[2] Ordway Res Inst, Albany, NY 12208 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 01期
关键词：
D O I：
10.1128/AAC.49.1.461-463.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A Monte Carlo simulation demonstrated that 1 g of meropenem (MEM) every 8 h (q8h) (3-h infusion) has a higher target attainment rate against Pseudomonas aeruginosa than either 500 mg of MEM q8h (3-h infusion) or 0.5 g of imipenem-cilastatin (I-C) q6h (1-h infusion). For other pathogens, 500 mg of MEM q8h was equivalent or superior to I-C.
引用
收藏
页码：461 / 463
页数：3
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