A Deathly DNase Activity for Dicer

被引：0
|
作者：
Okamura, Katsutomo [1 ]
Lai, Eric C. [1 ]
机构：
[1] Sloan Kettering Inst, Dept Dev Biol, New York, NY 10065 USA
来源：
DEVELOPMENTAL CELL | 2010年 / 18卷 / 05期
关键词：
CELL-DEATH; APOPTOTIC NUCLEASES; GENE CED-3; RIBONUCLEASE; DISCOVERY; INDUCTION; CLEAVAGE; ENZYME;
D O I：
10.1016/j.devcel.2010.05.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recently reporting in Science, Nakagawa et al. describe an unexpected role for Dicer in chromosome fragmentation during apoptosis in C. elegans. They find that cleavage of DCR-1 by the caspase CED-3 redirects its regulatory activity, by destroying its dsRNase activity while activating an intrinsic DNase activity.
引用
收藏
页码：692 / 694
页数：3
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