Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights

被引：89
|
作者：
Farooqi, Ammad Ahmad [1 ]
de la Roche, Marc [2 ]
Djamgoz, Mustafa B. A. [3 ,4 ]
Siddik, Zahid H. [5 ]
机构：
[1] IBGE, Islamabad, Pakistan
[2] Univ Cambridge, Dept Biochem, 80 Tennis Court Rd, Cambridge CB2 1GA, England
[3] Imperial Coll London, Dept Life Sci, Neurosci Solut Canc Res Grp, South Kensington Campus, London SW7 2AZ, England
[4] Cyprus Int Univ, Biotechnol Res Ctr, Mersin 10, Haspolat, North Cyprus, Turkey
[5] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
来源：
SEMINARS IN CANCER BIOLOGY | 2019年 / 58卷
关键词：
DEATH RECEPTOR 5; SODIUM-CHANNEL EXPRESSION; TRAIL-INDUCED APOPTOSIS; POLYPOSIS-COLI PROTEIN; TUMOR-SUPPRESSOR; BETA-CATENIN; IN-VITRO; CHROMOSOMAL INSTABILITY; UP-REGULATION; DOWN-REGULATION;
D O I：
10.1016/j.semcancer.2019.01.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on insights gleaned from almost a quarter century of research, it is obvious that deregulation of spatio-temporally controlled signaling pathways play instrumental role in development and progression of colorectal cancer. High-throughput technologies have helped to develop a sharper and broader understanding of the wide ranging signal transduction cascades which also contribute to development of drug resistance, loss of apoptosis and, ultimately, of metastasis. In this review, we have set the spotlight on role of JAK/STAT, TGF/SMAD, Notch, WNT/beta-Catenin, SHH/GLI and p53 pathways in the development and progression of colorectal cancer. We have also highlighted recent reports on TRAIL-mediated pathways and molecularly distinct voltage-gated sodium channels in colorectal cancer.
引用
收藏
页码：65 / 79
页数：15
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