Fragment-Based Screening of the Bromodomain of ATAD2

被引：64
|
作者：
Harner, Mary J. [1 ]
Chauder, Brian A. [1 ]
Phan, Jason [1 ]
Fesik, Stephen W. [1 ]
机构：
[1] Vanderbilt Univ, Dept Biochem, Sch Med, Nashville, TN 37232 USA
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 57卷 / 22期
基金：
美国国家卫生研究院;
关键词：
HIGH-AFFINITY LIGANDS; COREGULATOR ANCCA; PROTEIN; CANCER; NMR; COACTIVATOR; DESIGN; BREAST;
D O I：
10.1021/jm501035j
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cellular and genetic evidence suggest that inhibition of ATAD2 could be a useful strategy to treat several types of cancer. To discover small-molecule inhibitors of the bromodomain of ATAD2, we used a fragment-based approach. Fragment hits were identified using NMR spectroscopy, and ATAD2 was crystallized with three of the hits identified in the fragment screen.
引用
收藏
页码：9687 / 9692
页数：6
相关论文
共 50 条
  • [1] Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors
    Demont, Emmanuel H.
    Chung, Chun-wa
    Furze, Rebecca C.
    Grandi, Paola
    Michon, Anne-Marie
    Wellaway, Chris
    Barrett, Nathalie
    Bridges, Angela M.
    Craggs, Peter D.
    Diallo, Hawa
    Dixon, David P.
    Douault, Clement
    Emmons, Amanda J.
    Jones, Emma J.
    Karamshi, Bhumika V.
    Locke, Kelly
    Mitchell, Darren J.
    Mouzon, Bernadette H.
    Prinjha, Rab K.
    Roberts, Andy D.
    Sheppard, Robert J.
    Watson, Robert J.
    Bamborough, Paul
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (14) : 5649 - 5673
  • [2] Chemical synthesis of the ATAD2 bromodomain
    Creech, Gardner S.
    Paresi, Chelsea
    Li, Yue-Ming
    Danishefsky, Samuel J.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (08) : 2891 - 2896
  • [3] A Chemical Probe for the ATAD2 Bromodomain
    Bamborough, Paul
    Chung, Chun-wa
    Demont, Emmanuel H.
    Furze, Rebecca C.
    Bannister, Andrew J.
    Che, Ka Hing
    Diallo, Hawa
    Douault, Clement
    Grandi, Paola
    Kouzarides, Tony
    Michon, Anne-Marie
    Mitchell, Darren J.
    Prinjha, Rab K.
    Rau, Christina
    Robson, Samuel
    Sheppard, Robert J.
    Upton, Richard
    Watson, Robert J.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (38) : 11382 - 11386
  • [4] Genomic alteration of bromodomain protein ATAD2 in cancer
    Takeda, Tomoyo
    Matsumura, Yuta
    Nagasaki, Hirotoshi
    Eguchi, Ken
    Takatsuka, Miki
    Shinkai, Yoichi
    Nakagawa, Hiroyuki
    Kawashima, Hitoshi
    Ueno, Hiroyuki
    Li, Chiang J.
    [J]. CANCER RESEARCH, 2014, 74 (19)
  • [5] Exploring ATAD2 bromodomain function in the dynamic epigenetic landscape
    Malone, Kiera
    Glass, Karen
    [J]. FASEB JOURNAL, 2022, 36
  • [6] Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors
    Bamborough, Paul
    Chung, Chun-wa
    Furze, Rebecca C.
    Grandi, Paola
    Michon, Anne-Marie
    Sheppard, Robert J.
    Barnett, Heather
    Diallo, Hawa
    Dixon, David P.
    Douault, Clement
    Jones, Emma J.
    Karamshi, Bhumika
    Mitchell, Darren J.
    Prinjha, Rab K.
    Rau, Christina
    Watson, Robert J.
    Wemer, Thilo
    Demont, Emmanuel H.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (15) : 6151 - 6178
  • [7] The identification of new ATAD2 bromodomain inhibitors: the application of combined ligand and structure-based virtual screening
    Sepehri, B.
    Ghavami, R.
    [J]. SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2017, 28 (12) : 957 - 971
  • [8] Fragment-based design, synthesis and biological evaluation of theophylline derivatives as ATAD2 inhibitors in BT-549 cells
    Yao, Dahong
    You, Jieshu
    Yang, Xuetao
    Zhang, Jin
    Yao, Xiaojun
    [J]. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023, 38 (01)
  • [9] Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain
    Evans, Chiara M.
    Phillips, Margaret
    Malone, Kiera L.
    Tonelli, Marco
    Cornilescu, Gabriel
    Cornilescu, Claudia
    Holton, Simon J.
    Gorjanacz, Matyas
    Wang, Liping
    Carlson, Samuel
    Gay, Jamie C.
    Nix, Jay C.
    Demeler, Borries
    Markley, John L.
    Glass, Karen C.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (17)
  • [10] Disulfide bridge formation influences ligand recognition by the ATAD2 bromodomain
    Gay, Jamie C.
    Eckenroth, Brian E.
    Evans, Chiara M.
    Langini, Cassiano
    Carlson, Samuel
    Lloyd, Jonathan T.
    Caflisch, Amedeo
    Glass, Karen C.
    [J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2019, 87 (02) : 157 - 167
12345