Genetic polymorphisms of DNA repair gene XRCC1 and risk of uterine leiomyoma

被引：6
|
作者：
Yang, Yang [1 ]
Zhai, Xian Dun [2 ]
Gao, Lin Bo [1 ]
Li, Shi Liu [1 ]
Wang, Zheng [1 ]
Chen, Guo Di [1 ]
机构：
[1] Sichuan Univ, Dept Forens Biol, W China Sch Preclin & Forens Med, Chengdu 610041, Sichuan, Peoples R China
[2] Hennan Univ Sci & Technol, Inst Forens Med, Luoyang 471003, Henan, Peoples R China
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2010年 / 338卷 / 1-2期
关键词：
Genetic polymorphism; Uterine leiomyoma; XRCC1; STRAND BREAK REPAIR; CANCER-RISK; LUNG-CANCER; METAANALYSIS; SUSCEPTIBILITY; POPULATIONS; ARG399GLN;
D O I：
10.1007/s11010-009-0347-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The objective was to study the relationship between the polymorphisms of the DNA repair gene XRCC1 Arg399Gln, Arg194Trp, and Arg280His uterine leiomyoma in a Chinese population. In the case-control study, we compared the XRCC1 gene polymorphism of 136 uterine leiomyoma patients and 140 healthy controls by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The results suggested that the genotype Arg/Arg of codon 280 was significantly different from its heterozygote (odds ratio [OR] = 3.633, 95% confidence interval [CI]: 2.147-6.148). In conclusion, the results suggest that polymorphism of XRCC1 Arg280His was associated with the increased risk of uterine leiomyoma in a Chinese population.
引用
收藏
页码：143 / 147
页数：5
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