Visible-Light-Induced Trifluoromethylation of Allylic Alcohols

被引：19

作者：

Li, Bowen ^{[1
]}

Zeng, Wubing ^{[1
]}

Wang, Lin ^{[1
]}

Geng, Zhishuai ^{[2
]}

Loh, Teck-Peng ^{[3
]}

Xie, Peizhong ^{[1
]}

机构：

[1] Nanjing Tech Univ, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China

[2] Beijing Inst Technol, Sch Mat Sci & Engn, Beijing 100081, Peoples R China

[3] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 13期

基金：

中国国家自然科学基金;

关键词：

COPPER-CATALYZED TRIFLUOROMETHYLATION; STEREOSELECTIVE-SYNTHESIS; ALKENES; OXYTRIFLUOROMETHYLATION; FLUORINATION; ANALOGS;

D O I：

10.1021/acs.orglett.1c01767

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An organic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developed in an environmentally benign manner. In this reaction, the readily available CF3SO2Na was selected as the trifluoromethylation reagent. The in situ generated byproduct SO2 was reutilized to activate C-OH bond, which enabled this dehydroxylative trifluoromethylation to be performed conveniently. A variety of multifunctionalized CF3-allylic compounds were obtained in high yields and excellent stereoselectivity.

引用

页码：5235 / 5240

页数：6

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