A novel highly stereoselective total synthesis of epothilone B and of its (12R,13R) acetonide

被引：26
|
作者：
Mulzer, J [1 ]
Karig, G [1 ]
Pojarliev, P [1 ]
机构：
[1] Univ Vienna, Inst Organ Chem, A-1090 Vienna, Austria
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 40期
基金：
奥地利科学基金会;
关键词：
asymmetric synthesis; antitumor compounds; oxazolidinone; hydroxylation;
D O I：
10.1016/S0040-4039(00)01318-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Stereoselective syntheses of epothilone B (1) and its novel derivative 2 are described. Key steps are the formation of intermediate 3 via Sharpless AD-reaction and Davis-Evans-hydroxylation. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7635 / 7638
页数：4
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