Inhibition of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) by D-005 (A lipid extract of Acrocomia crispa fruits)

被引：0
|
作者：
Perez, Yohani [1 ]
Oyarzabal, Ambar [1 ]
Sierra, Roxana [1 ]
Mas, Rosa [1 ]
Molina, Vivian [1 ]
Jimenez, Sonia [1 ]
Gonzalez, Victor [1 ]
机构：
[1] Natl Ctr Sci Res, Ctr Nat Prod, Pharmacol Dept, Havana, Cuba
来源：
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS | 2017年 / 16卷 / 03期
关键词：
Acrocomia crispa; anti-inflammatory; COX; dual inhibition; 5-LOX; BENIGN PROSTATIC HYPERPLASIA; ROYSTONEA-REGIA FRUITS; ROYAL PALM FRUIT; IN-VITRO; ANTIINFLAMMATORY DRUGS; GROUND FRUITS; ANTIOXIDANT; RATS; BPH; SUBSTANCES;
D O I：
暂无
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
This study was aimed to investigate whether the a lipid extract from Acrocomia crispa fruits (D-005) inhibits COX and 5-LOX enzyme activities in vitro. This study demonstrates that D-005 inhibits markedly and in a dose dependent manner COX-2 and 5-LOX activities. The dual inhibition of COX-2 and 5-LOX supports further research on the potential anti-inflammatory effect of D-005.
引用
收藏
页码：319 / 328
页数：10
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