Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo

被引：178
|
作者：
Castleberry, Steven A. [1 ,2 ,3 ,4 ]
Almquist, Benjamin D. [1 ,2 ,3 ]
Li, Wei [1 ,2 ]
Reis, Tiago [1 ]
Chow, John [1 ]
Mayner, Sarah [1 ]
Hammond, Paula T. [1 ,2 ,3 ]
机构：
[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[2] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
[3] MIT, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA
[4] Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA
来源：
ADVANCED MATERIALS | 2016年 / 28卷 / 09期
基金：
美国国家卫生研究院;
关键词：
MATRIX-METALLOPROTEINASE INHIBITORS; FOOT ULCERS; MULTILAYER FILMS; STEM-CELL; SIRNA; MATRIX-METALLOPROTEINASE-9; DELIVERY; THERAPY; SKIN; EXPRESSION;
D O I：
10.1002/adma.201503565
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The direct local delivery of short interfering RNA (siRNA) into target tissues presents a real solution to several complex medical conditions that today lack efficacious therapies. The development of an ultrathin polymer coating is described to sustain the delivery of siRNA for up to 2 weeks in vitro and in vivo. This technology successfully reduces the expression of MMP-9 within the wounds of diabetic mice, significantly accelerating the wound healing process and improving the quality of tissue formed. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1809 / 1817
页数：9
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