Heart rate variability as an indicator for morphine pharmacokinetics and pharmacodynamics in critically ill newborn infants

被引：0
|
作者：
Bressan, Nadja [1 ,2 ]
McGregor, Carolyn [1 ]
Smith, Kathy [1 ]
Lecce, Loreto [2 ]
James, Andrew [2 ,3 ]
机构：
[1] Univ Ontario, Fac Business & Informat Technol, Inst Technol, Oshawa, ON, Canada
[2] Hosp Sick Children, Div Neonatol, Toronto, ON M5G 1X8, Canada
[3] Univ Toronto, Dept Paediat, Toronto, ON M5S 1A1, Canada
来源：
2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | 2014年
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D O I：
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中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Morphine is the commonest drug used for analgesia in newborn infants. It is a natural opioid that acts as an agonist at the mu and kappa receptors, which are receptors for analgesia and sedation. Morphine pharmacokinetics and pharmacodynamics (PKPD) for the newborn infant population are not well understood. The objective of this study is to use morphine PKPD parameters to estimate morphine plasma concentrations to be correlated with heart rate variability in the neonatal population.
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页码：5719 / 5722
页数：4
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