Imaging as a Strategy for Premortem Diagnosis and Staging of Tauopathies

被引：10

作者：

Kim, S. ^{[1
]}

Jensen, J. R. ^{[1
]}

Cisek, K. ^{[1
]}

Funk, K. E. ^{[1
]}

Naphade, S. ^{[1
]}

Schafer, K. ^{[1
]}

Kuret, J. ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Mol Neurobiol, Dept Mol & Cellular Biochem, Coll Med, Columbus, OH 43210 USA

来源：

CURRENT ALZHEIMER RESEARCH | 2010年 / 7卷 / 03期

关键词：

Alzheimer's disease; frontotemporal lobar degeneration; tau; neurofibrillary tangle; paired helical filaments; POSITRON-EMISSION-TOMOGRAPHY; MOLECULAR-DYNAMICS SIMULATIONS; PAIRED HELICAL FILAMENTS; ALZHEIMERS-DISEASE; HUMAN BRAIN; NEUROFIBRILLARY TANGLES; COGNITIVE IMPAIRMENT; MONOAMINE-OXIDASE; AMYLOID PLAQUES; BINDING-SITES;

D O I：

10.2174/156720510791050894

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease is diagnosed by postmortem detection of pathological lesions that accumulate in specific brain regions. Although the presence of both beta-amyloid plaques and tau-bearing neurofibrillary lesions defines Alzheimer's disease, the distribution of neurofibrillary lesions alone correlates strongly with neurodegeneration and cognitive decline. A whole-brain imaging test capable of detecting these lesions in premortem cases could have great potential for staging and differentially diagnosing Alzheimer's disease. Here we discuss the challenges in developing a whole-brain imaging approach for detection of this intracellular target.

引用

页码：230 / 234

页数：5

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