Measurement of refractive index distribution of biotissues by scanning focused refractive index microscopy

被引：0

作者：

Sun, Teng-Qian ^{[1
]}

Ye, Qing ^{[1
]}

Wang, Xiao-Wan ^{[1
]}

Wang, Jin ^{[1
]}

Deng, Zhi-Chao ^{[1
]}

Mei, Jian-Chun ^{[2
]}

Zhou, Wen-Yuan ^{[2
]}

Zhang, Chun-Ping ^{[1
]}

Tian, Jian-Guo ^{[1
]}

机构：

[1] Nankai Univ, Sch Phys, Key Lab Weak Light Nonlinear Photon, Minist Educ, Tianjin 300071, Peoples R China

[2] Nankai Univ, Adv Technol Inst, Tianjin 300071, Peoples R China

来源：

OPTICS IN HEALTH CARE AND BIOMEDICAL OPTICS VI | 2014年 / 9268卷

基金：

对外科技合作项目（国际科技项目）;

关键词：

scanning focused refractive index microscopy; biological tissues; refractive index imaging; DIGITAL HOLOGRAPHIC MICROSCOPY; LIVING CELLS;

D O I：

10.1117/12.2072026

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We adapt the improved scanning focused refractive-index microscopy (SFRIM) technique to the quantitative study of biological tissues. Delicate refractive index (RI) imaging of a porcine muscle tissue is obtained in a reflection mode. Some modifications are made to the SFRIM for better two dimension (2-D) observation of the tissues. The RI accuracy is 0.002. The central spatial resolution of SFRIM achieves 1 mu m, smaller than the size of the focal spot. Our method is free from signal distortion. The experimental result demonstrates that SFRIM is a potential technique in a wide field of biomedical research.

引用

页数：7

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