Antiproliferative Effect of Phellodendron amurense Rupr. Based on Angiogenesis

被引：12

作者：

Balazova, Ludmila ^{[1
]}

Kurhajec, Slavomir ^{[1
]}

Kello, Martin ^{[2
]}

Bedlovicova, Zdenka ^{[3
]}

Zigova, Martina ^{[2
]}

Petrovova, Eva ^{[4
]}

Benova, Katarina ^{[5
]}

Mojzis, Jan ^{[2
]}

Eftimova, Jarmila ^{[1
]}

机构：

[1] Univ Vet Med & Pharm Kosice, Dept Pharmaceut Technol Pharmacognosy & Bot, Kosice 04181, Slovakia

[2] Safarik Univ, Fac Med, Dept Pharmacol, Trieda SNP 1, Kosice 04011, Slovakia

[3] Univ Vet Med & Pharm Kosice, Dept Chem Biochem & Biophys, Kosice 04181, Slovakia

[4] Univ Vet Med & Pharm Kosice, Dept Morphol Disciplines, Kosice 04181, Slovakia

[5] Univ Vet Med & Pharm Kosice, Dept Biol & Physiol, Kosice 04181, Slovakia

来源：

LIFE-BASEL | 2022年 / 12卷 / 05期

关键词：

angiogenesis; berberine; cancer; Phellodendron amurense; CAM; COLLAGEN-INDUCED ARTHRITIS; CORTEX PHELLODENDRI; BARK EXTRACT; BERBERINE; NEXRUTINE; ALKALOIDS; CARCINOMA; MODEL; AUTOPHAGY; ARTEMIA;

D O I：

10.3390/life12050767

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Phellodendron amurense Rupr. is medicinal plant used for supplemental therapy of various diseases based on their positive biological activities. The aim of this study was evaluated the main metabolite, safety of application and anticancer potential. Berberine was determined by HPLC as main alkaloid. Harmful character was determined by irritation test in ovo. The potential cancerogenic effect was studied in vitro on a cellular level, in ovo by CAM assay and in vivo on whole organism Artemia franciscana. Extract from the bark of Phellodendron amurense showed antiproliferative and antiangiogenic effects. The results of our work showed promising anticancer effects based also on the inhibition of angiogenesis with minimum negative effects.

引用

页数：18

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