False-negative result of serum cryptococcal antigen lateral flow assay in an HIV-infected patient with culture-proven cryptococcaemia

被引：15
|
作者：
Santa Barbara Borges, Moara Alves [1 ]
de Araujo Filho, Joao Alves [1 ,2 ,3 ]
Ascenco Soares, Renata de Bastos [2 ,3 ]
Vidal, Jose Ernesto [4 ,5 ]
Turchi, Marllia Dalva [1 ,3 ]
机构：
[1] Univ Fed Goias, Inst Patol Trop & Saude Publ, R 235,S-N Setor Leste Univ, BR-74605450 Goiania, Go, Brazil
[2] Pontificia Univ Catolica Goias, R 235,15 Setor Leste Univ, BR-74605050 Goiania, Go, Brazil
[3] Hosp Estadual Doencas Trop Dr AnuarAuad, Alameda Contorno 3556, BR-74850400 Goiania, Go, Brazil
[4] Inst Infectol Emilio Ribas, Av Doutor Arnaldo 165, BR-01246900 Sao Paulo, SP, Brazil
[5] Univ Sao Paulo, Fac Med, Hosp Clin, Av Dr Eneas de Carvalho Aguiar 255, BR-05403000 Sao Paulo, SP, Brazil
来源：
MEDICAL MYCOLOGY CASE REPORTS | 2019年 / 26卷
关键词：
Cryptococcosis; AIDS; Fungal antigens; False negative reaction; Prozone effect; MENINGITIS; DIAGNOSIS;
D O I：
10.1016/j.mmcr.2019.10.009
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The detection of cryptococcal capsular antigen (CrAg) is very sensitive and specific, however false-negative results have been reported, mostly in cerebrospinal fluid. We report the case of an HIV-infected patient with CD4 = 42 cells/mL, asthenic, negative serum CrAg lateral flow assay (LFA) and culture-proven cryptococcaemia. Despite the high accuracy of LFA, false-negative result is possible. Careful clinical evaluation and close follow-up are relevant.
引用
收藏
页码：64 / 66
页数：3
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