Prenatal exposure to exogenous progesterone adversely affects fetal development in Albino rats

被引：1

作者：

Tag, Hend M. ^{[1
,2
]}

Elgawish, Rania Abdelrahman ^{[3
]}

Ebaid, Hala M. ^{[1
]}

Abdel-Rahman, Mona ^{[1
]}

Abdelrazek, Heba M. A. ^{[4
]}

机构：

[1] Suez Canal Univ, Dept Zool, Fac Sci, Ismailia, Egypt

[2] Univ Jeddah Branch Khulais Governorate Girls Sect, Dept Biol, Coll Sci & Art, Jeddah, Saudi Arabia

[3] Suez Canal Univ, Dept Forens Med & Toxicol, Fac Vet Med, Ismailia, Egypt

[4] Suez Canal Univ, Dept Physiol, Fac Vet Med, Ismailia, Egypt

来源：

JOURNAL OF BASIC AND APPLIED ZOOLOGY | 2021年 / 82卷 / 01期

关键词：

Fetuses; Progesterone; Rats; Skeletal defects; Visceral organs;

D O I：

10.1186/s41936-021-00212-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

BackgroundThe current study was carried out to investigate the effects of exogenous progesterone on fetal development in rats.ResultsPlacental weights did not vary in control and treated groups. Fetal weights were significantly reduced in the low- and high-dose progesterone groups. Fetal CVL was significantly reduced in both treatment groups compared to control group. In fetuses that received maternal treatment with low- and high-dose progesterone, several parts of the fetal skeleton showed incomplete ossification. Alkaline phosphatase was decreased in the bones of fetuses born to progesterone-treated dams. The testes and ovaries of the fetuses of the dams treated with low and high doses of progesterone showed degenerative seminiferous tubules and failed sex cord development into primordial follicles, respectively.ConclusionsThe administration of exogenous progesterone during pregnancy adversely influences fetal growth, skeletal construction, and sex organ development.

引用

页数：12

共 50 条

[1] Prenatal exposure to exogenous progesterone adversely affects fetal development in Albino rats
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Rania Abdelrahman Elgawish
Hala M. Ebaid
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Heba M. A. Abdelrazek
[J]. The Journal of Basic and Applied Zoology, 82 (1):
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