Cell Cycle Regulators and Lineage-Specific Therapeutic Targets for Cushing Disease

被引：6

作者：

Araki, Takako ^{[1
]}

Liu, Ning-Ai ^{[2
]}

机构：

[1] Univ Minnesota, Dept Med, Div Diabet Endocrinol & Metab, Box 736 UMHC, Minneapolis, MN 55455 USA

[2] Cedars Sinai Med Ctr, Dept Med, Pituitary Ctr, Los Angeles, CA 90048 USA

来源：

FRONTIERS IN ENDOCRINOLOGY | 2018年 / 9卷

关键词：

pituitary tumor; Cushing disease; cell cycle; cyclin E; E2F1; POMC; MULTIPLE ENDOCRINE NEOPLASIA; HUMAN PITUITARY-ADENOMAS; RETINOBLASTOMA SUSCEPTIBILITY GENE; GROWTH-FACTOR RECEPTOR; TUMOR-SUPPRESSOR GENE; DEPENDENT KINASES; INHIBITOR P27; CORTICOTROPH TUMORS; CDK INHIBITOR; MICE LACKING;

D O I：

10.3389/fendo.2018.00444

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cell cycle proteins are critical to pituitary development, but their contribution to lineage-specific tumorigenesis has not been well-elucidated. Emerging evidence from in vitro human tumor analysis and transgenic mouse models indicates that G1/S-related cell cycle proteins, particularly cyclin E, p27, Rb, and E2F1, drive molecular mechanisms that underlie corticotroph-specific differentiation and development of Cushing disease. The aim of this review is to summarize the literature and discuss the complex role of cell cycle regulation in Cushing disease, with a focus on identifying potential targets for therapeutic intervention in patients with these tumors.

引用

页数：8

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