Early classification of Alzheimer's disease using hippocampal texture from structural MRI

被引：4
|
作者：
Zhao, Kun [1 ]
Ding, Yanhui [1 ]
Wang, Pan [2 ]
Dou, Xuejiao [3 ,4 ,7 ]
Zhou, Bo [2 ]
Yao, Hongxiang [5 ]
An, Ningyu [5 ]
Zhang, Yongxin [8 ]
Zhang, Xi [2 ]
Liu, Yong [3 ,4 ,6 ,7 ]
机构：
[1] Shandong Normal Univ, Sch Informat Sci & Engn, Jinan 250014, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Inst Geriatr & Gerontol, Dept Neurol, Beijing 100853, Peoples R China
[3] Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
[4] Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
[5] Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing 100853, Peoples R China
[6] Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
[7] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[8] Shandong Normal Univ, Sch Math & Stat, Jinan 250014, Peoples R China
来源：
MEDICAL IMAGING 2017: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING | 2017年 / 10137卷
基金：
中国国家自然科学基金;
关键词：
Image textures; Hippocampus; Alzheimer's disease; Support vector machine; Classification; MILD COGNITIVE IMPAIRMENT; VOXEL-BASED MORPHOMETRY; RESTING-STATE FMRI; FUNCTIONAL CONNECTIVITY; DIAGNOSTIC-CRITERIA; IMAGING BIOMARKERS; REGISTRATION;
D O I：
10.1117/12.2254198
中图分类号：
TP18 [人工智能理论];
学科分类号：
081104 ; 0812 ; 0835 ; 1405 ;
摘要：
Convergent evidence has been collected to support that Alzheimer's disease (AD) is associated with reduction in hippocampal volume based on anatomical magnetic resonance imaging (MRI) and impaired functional connectivity based on functional MRI. Radiomics texture analysis has been previously successfully used to identify MRI biomarkers of several diseases, including AD, mild cognitive impairment and multiple sclerosis. In this study, our goal was to determine if MRI hippocampal textures, including the intensity, shape, texture and wavelet features, could be served as an MRI biomarker of AD. For this purpose, the texture marker was trained and evaluated from MRI data of 48 AD and 39 normal samples. The result highlights the presence of hippocampal texture abnormalities in AD, and the possibility that texture may serve as a neuroimaging biomarker for AD.
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页数：7
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