The Angiogenic Balance and Its Implications in Cancer and Cardiovascular Diseases: An Overview

被引：7

作者：

Ionescu, Catalina ^{[1
]}

Oprea, Bogdan ^{[2
]}

Ciobanu, Georgeta ^{[1
]}

Georgescu, Milena ^{[3
]}

Bica, Ramona ^{[4
]}

Mateescu, Garofita-Olivia ^{[2
]}

Huseynova, Fidan ^{[5
,6
,7
]}

Barragan-Montero, Veronique ^{[5
]}

机构：

[1] Univ Craiova, Fac Sci, Dept Chem, 107i Calea Bucuresti, Craiova 200144, Romania

[2] Univ Med & Pharm, Histol Dept, 2-4 Petru Rares, Craiova 200349, Romania

[3] Cty Emergency Hosp Craiova, Clin Plast Surg & Burns, Craiova 200642, Romania

[4] Gen Hosp Victor Babes, 281 Mihai Bravu St,Sect 3, Bucharest 030303, Romania

[5] Univ Montpellier, LBN, F-34193 Montpellier, France

[6] Azerbaijan Natl Acad Sci ANAS, Inst Mol Biol & Biotechnol, AZ-1073 Baku, Azerbaijan

[7] Azerbaijan Med Univ, Dept Histol Cytol & Embryol, AZ-1078 Baku, Azerbaijan

来源：

MEDICINA-LITHUANIA | 2022年 / 58卷 / 07期

关键词：

angiogenesis; activators; inhibitors; cancer; cardiovascular diseases; ENDOTHELIAL GROWTH-FACTOR; METASTATIC COLORECTAL-CANCER; ISCHEMIC-HEART-DISEASE; THERAPEUTIC ANGIOGENESIS; GENE-THERAPY; MOLECULAR-MECHANISMS; TUMOR VASCULATURE; SPROUTING ANGIOGENESIS; INHIBITS ANGIOGENESIS; SIGNALING PATHWAY;

D O I：

10.3390/medicina58070903

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiogenesis is the process of developing new blood vessels from pre-existing ones. This review summarizes the main features of physiological and pathological angiogenesis and those of angiogenesis activation and inhibition. In healthy adults, angiogenesis is absent apart from its involvement in female reproductive functions and tissue regeneration. Angiogenesis is a complex process regulated by the action of specific activators and inhibitors. In certain diseases, modulating the angiogenic balance can be a therapeutic route, either by inhibiting angiogenesis (for example in the case of tumor angiogenesis), or by trying to activate the process of new blood vessels formation, which is the goal in case of cardiac or peripheral ischemia.

引用

页数：19

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