Erosion of Thin-Cap Fibroatheroma in an Area of Low Endothelial Shear Stress Anatomy and Local Hemodynamic Environment Dictate Outcomes

被引:10
|
作者
Giannopoulos, Andreas A. [1 ]
Antoniadis, Antonios P. [2 ]
Croce, Kevin [1 ]
Chatzizisis, Yiannis S. [3 ]
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc, Boston, MA 02115 USA
[2] Guys & St Thomas NHS Fdn Trust, Cardiovasc Dept, London, England
[3] Univ Nebraska Med Ctr, Div Cardiovasc, 982265 Nebraska Med Ctr, Omaha, NE 68198 USA
关键词
acute coronary syndrome(s); atherosclerosis; coronary arteries; erosion; shear stress; APOPTOSIS;
D O I
10.1016/j.jcin.2016.01.011
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:E77 / E78
页数:2
相关论文
共 14 条
  • [1] Rupture of a stenotic thin-cap fibroatheroma in an area of low endothelial shear stress Implication for mechanism of acute coronary syndromes
    Giannopoulos, Andreas A.
    Zhao, Shijia
    Chatzizisis, Yiannis S.
    [J]. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2018, 19 (08) : 950 - 951
  • [2] Thin-Cap Fibroatheroma Rupture Is Associated With a Fine Interplay of Shear and Wall Stress
    Pedrigi, Ryan M.
    de Silva, Ranil
    Bovens, Sandra M.
    Mehta, Vikram V.
    Petretto, Enrico
    Krams, Rob
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2014, 34 (10) : 2224 - 2231
  • [3] TRANSCRIPTOME ANALYSIS OF LOCAL SHEAR DEPENDENT GENE EXPRESSION IN ENDOTHELIAL CELLS DURING THIN-CAP FIBROATHEROMA(TCFA) DEVELOPMENT
    Homma, T.
    Caurette, P.
    Silva, H. J.
    Yamada, I.
    Makrydaki, E.
    Bovens, S.
    Pedrigi, R.
    Petretto, E. G.
    Krams, R.
    [J]. ATHEROSCLEROSIS, 2014, 237 (02) : E9 - E9
  • [4] Relationship between high shear stress and OCT-verified thin-cap fibroatheroma in patients with coronary artery disease
    Okamoto, Naotaka
    Vengrenyuk, Yuliya
    Fuster, Valentin
    Samady, Habib
    Yasumura, Keisuke
    Baber, Usman
    Barman, Nitin
    Suleman, Javed
    Sweeny, Joseph
    Krishnan, Prakash
    Mehran, Roxana
    Sharma, Samin K.
    Narula, Jagat
    Kini, Annapoorna S.
    [J]. PLOS ONE, 2020, 15 (12):
  • [5] Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques
    Seneviratne, Anusha N.
    Cole, Jennifer E.
    Goddard, Michael E.
    Park, Inhye
    Mohri, Zahra
    Sansom, Stephen
    Udalova, Irina
    Krams, Rob
    Monaco, Claudia
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2015, 89 : 168 - 172
  • [6] Adventitial inflammation is associated with thin-cap atheromas and expression of matrix-degrading enzymes and occurs in coronary regions exposed to low endothelial shear stress
    Antoniadis, A. P.
    Papafaklis, M. I.
    Chatzizisis, Y. S.
    Sukhova, G. K.
    Baker, A. B.
    Coskun, A. U.
    Takahashi, S.
    Edelman, E. R.
    Stone, P. H.
    Feldman, C. L.
    [J]. EUROPEAN HEART JOURNAL, 2012, 33 : 944 - 945
  • [7] Low endothelial shear stress promotes the differentiation of early atherosclerotic lesions to thin cap fibroatheromas
    Chatzizisis, Yiannis S.
    Jonas, Michael
    Coskun, Ahmet U.
    Beigel, Roy
    Stone, Benjamin V.
    Maynard, Charles
    Gerrity, Ross G.
    Daley, William
    Rogers, Campbell
    Edelman, Elazer R.
    Feldman, Charles L.
    Stone, Peter H.
    [J]. CIRCULATION, 2007, 116 (16) : 114 - 114
  • [8] Low endothelial shear stress upregulates extracellular matrix degrading enzymes and promotes the formation of thin cap fibroatheromas in the coronary arteries
    Chatzizisis, Yiannis S.
    Baker, Aaron B.
    Beigel, Roy
    Jonas, Michael
    Coskun, Ahmet U.
    Stone, Benjamin V.
    Maynard, Charles
    Gerrity, Ross
    Edelman, Elazer R.
    Stone, Peter H.
    Feldman, Charles L.
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (06) : E44 - E44
  • [9] Low endothelial shear stress determines the formation of coronary thin cap fibroatheromas through upregulation of extracellular matrix degrading enzymes
    Chatzizisis, Y. C.
    Baker, A. B.
    Beigel, R.
    Jonas, M.
    Coskun, A. U.
    Stone, B. V.
    Maynard, C.
    Feldman, C. L.
    Stone, P. H.
    Edelman, E. R.
    [J]. EUROPEAN HEART JOURNAL, 2008, 29 : 128 - 128
  • [10] "Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques" (vol 89B, pg 168, 2015)
    Seneviratne, Anusha N.
    Cole, Jennifer E.
    Goddard, Michael E.
    Park, Inhye
    Mohri, Zahra
    Sansom, Stephen
    Udalova, Irina
    Krams, Rob
    Monaco, Claudia
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2016, 91 : 10 - 10