Comparative study of the effect of neoadjuvant chemotherapy followed by radical hysterectomy versus chemoradiotherapy in locally advanced cervical cancer (stage Ib2_IIb): a retrospective cohort study

Background: Despite many advances, locally advanced cervical carcinoma (LACC) is one of the most important and challenging stage in treatment of cervical cancer. Material and methods: The present study is a retrospective cohort study that was conducted on 67 patients between 2012 and 2019. Inclusion criteria were patients with LACC( stage Ib2_IIb)that treated with NACT followed by RS (group 2) and chemo radiotherapy (group1). We evaluate staging of the disease, pathological indicators, indication of radiotherapy after surgery, duration of follow-up, the patient's condition at the last follow-up period and complications by studding patient's record. Data was analyzed using SPSS 20 and P<0.05 considered to be significant. Result: In term of recurrence, 13(36.1%) cases in group 1 were shown a recurrence in two years after treatment and in group 2,2patiente (10.5%) have recurrences in two years. In terms of recurrence, significant differences was shown between the two groups (P = 0.04). There was no significant difference in mortality rate between two groups using Chi-square test. One and two -year-disease free survival were observed in 27 (75%)and in 21 (58.3%)in group1 and in 19 ( 100%) and in 17 ( 89.5%) in group 2 respectively.The differences between two groups were significant (p=0.02 & p=0.03).Three- year- disease free- survival was observed in 13 (36.1%) and 10(52%) patients of group 1 and 2 respectively (p=.103) that was not significant. Conclusion: This research has shown that NACT followed RS is superior to chemo radiotherapy in term of relapse and DFS in one and two years in LACC.