Relevant biological processes for tissue development with stem cells and their mechanistic modeling: A review

被引:3
|
作者
Paim, Agata [1 ,2 ]
Cardozo, Nilo S. M. [1 ]
Tessaro, Isabel C. [1 ]
Pranke, Patricia [2 ,3 ]
机构
[1] Univ Fed Rio Grande do Sul, Dept Chem Engn, R Engn Luis Englert S-N, BR-90040040 Porto Alegre, RS, Brazil
[2] Univ Fed Rio Grande do Sul, Fac Pharm, Ave Ipiranga,2752, BR-90610000 Porto Alegre, RS, Brazil
[3] Stem Cell Res Inst, Porto Alegre, RS, Brazil
关键词
Stem cells; Biological processes; Tissue development; Three-dimensional scaffolds; Phenomenological modeling; HEPATOCYTE GROWTH-FACTOR; EXTRACELLULAR-MATRIX PRODUCTION; ENDOPLASMIC-RETICULUM STRESS; HUMAN UMBILICAL-CORD; ENGINEERED CARTILAGE; MATHEMATICAL-MODEL; ENDOTHELIAL-CELLS; STROMAL CELLS; COMPUTATIONAL-MODEL; OXYGEN GRADIENTS;
D O I
10.1016/j.mbs.2018.05.007
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A potential alternative for tissue transplants is tissue engineering, in which the interaction of cells and biomaterials can be optimized. Tissue development in vitro depends on the complex interaction of several biological processes such as extracellular matrix synthesis, vascularization and cell proliferation, adhesion, migration, death, and differentiation. The complexity of an individual phenomenon or of the combination of these processes can be studied with phenomenological modeling techniques. This work reviews the main biological phenomena in tissue development and their mathematical modeling, focusing on mesenchymal stem cell growth in three-dimensional scaffolds.
引用
收藏
页码:147 / 158
页数:12
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