Regulation of matrix metalloproteinases and their tissue inhibitors by transforming growth factor-β

被引：0
|
作者：
Lin, HY [1 ]
Wang, HM [1 ]
Zhu, C [1 ]
机构：
[1] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100080, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2003年 / 30卷 / 01期
关键词：
matrix metalloproteinases (MMPs); tissue inhibitors of MMPs (TIMPs); transforming growth factor-beta (TGF-beta); Smad pathway; MAPK signaling pathway; AP-1;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) play pivotal roles in the degradation and remodeling of the extracellular matrix (ECM). The cooperation and balanced expressions of MMPs and TIMPs are essential issues for the cyclic growth, differentiation, maintenance, and degradation of the tissues during physiologic and pathologic processes. Transforming growth factor-beta (TGF-beta) could perform its biological effect on ECM by regulating the gene expressions of MMPs and TIMPs. The different modulating effects of TGF-beta on MMPs and TIMPs in different cell types are due to the activating of Smad pathway, MAPK signaling pathway or inducing the formation of AP-1 complex by extracellular TGF-beta signal.
引用
收藏
页码：7 / 12
页数：6
相关论文
共 24 条
  • [1] Chenn A, 1999, AM J CLIN PATHOL, V112, P531
  • [2] GAIRE M, 1994, J BIOL CHEM, V269, P2032
  • [3] Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-β involves functional cooperation with p300/CBP transcriptional coactivators
    Ghosh, AK
    Yuan, W
    Mori, Y
    Varga, J
    [J]. ONCOGENE, 2000, 19 (31) : 3546 - 3555
  • [4] Human endometrial epithelial cells modulate the activation of gelatinase A by stromal cells
    Goffin, F
    Frankenne, F
    Béliard, A
    d'Hauterive, SP
    Pignon, MR
    Geenen, V
    Foidart, JM
    [J]. GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 2002, 53 (02) : 105 - 111
  • [5] Transforming growth factor-β- and tumor necrosis factor-α-mediated induction and proteolytic activation of MMP-9 in human skin
    Han, YP
    Tuan, TL
    Hughes, M
    Wu, HY
    Garner, WL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (25) : 22341 - 22350
  • [6] Cytokine-mediated regulation of 92-kilodalton type IV collagenase, tissue inhibitor of metalloproteinase-1 (TIMP-1), and TIMP-3 messenger ribonucleic acid expression in human endometrial stromal cells
    Huang, HY
    Wen, Y
    Irwin, JC
    Kruessel, JS
    Soong, YK
    Polan, ML
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (05): : 1721 - 1729
  • [7] Johansson N, 2000, J CELL SCI, V113, P227
  • [8] THE REGULATION OF AP-1 ACTIVITY BY MITOGEN-ACTIVATED PROTEIN-KINASES
    KARIN, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (28) : 16483 - 16486
  • [9] Regulation of matrix metalloproteinases (MMPs) and their tissue inhibitors in human myometrial smooth muscle cells by TGF-β1
    Ma, C
    Chegini, N
    [J]. MOLECULAR HUMAN REPRODUCTION, 1999, 5 (10) : 950 - 954
  • [10] Martin J, 2000, PERITON DIALYSIS INT, V20, P524
123