A convenient synthesis of 1-alkyl-1-phenylhydrazines from N-aminophthalimide

被引：16
|
作者：
Nara, S [1 ]
Sakamoto, T [1 ]
Miyazawa, E [1 ]
Kikugawa, Y [1 ]
机构：
[1] Josai Univ, Fac Pharmaceut Sci, Sakado, Saitama 3500295, Japan
来源：
SYNTHETIC COMMUNICATIONS | 2003年 / 33卷 / 01期
关键词：
phenylhydrazine; pyridine-borane; N-aminophthalimide; reductive amination;
D O I：
10.1081/SCC-120015563
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N-Alkylaminophthalimides were synthesized by condensation of N-aminophthalimide with aldehydes, and subsequent reduction of the intermediate with pyridine-borane in acetic acid. N-Phenylation and removal of the phthalimide group gave 1-alkyl-1-phenylhydrazines in high yield.
引用
收藏
页码：87 / 98
页数：12
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