Association of Neurotensin Receptor 1 Gene Polymorphisms with Processing Speed in Healthy Chinese-Han Subjects

被引:2
|
作者
Wang, Man [1 ,2 ]
Ma, Hui [3 ]
Huang, Ying-lin [1 ]
Zhu, Gang [1 ]
Zhao, Jing-ping [2 ]
机构
[1] China Med Univ, Dept Psychiat, Hosp 1, Shenyang, Peoples R China
[2] Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China
[3] Yanshan Univ, Ctr Mental Hlth, Qinhuangdao, Peoples R China
关键词
Neurotensin receptor 1; Gene polymorphisms; Processing speed; Executive function; Correlation; NEUROTENSIN; RECEPTORS; DOPAMINE; MEMORY;
D O I
10.1007/s12031-014-0404-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Neurotensin modulates dopamine and serotonin transmission in the brain. The study investigated whether genetic polymorphisms in the Neurotensin receptor 1 gene were associated with performance on processing speed and executive function. A total of 129 healthy Chinese-Han volunteers were recruited. Genotyping for three SNPs, including rs6090453, rs6011914, and rs2427422, was analyzed by using a PCR and a restriction fragment length polymorphism analysis. Performances of processing speed and executive function were assessed by using Trail Making Test-A (TMT-A), Wisconsin Card Sorting Test, and Stroop Color-Word Test. We found significant differences in the outcomes of TMT-A score among rs6090453C/G (F ((2,126)) = 4.405, P = 0.014) and rs2427422A/G (F ((2,126)) = 7.498, P = 0.001) genotypes. Neurotensin receptor 1 SNP polymorphisms were significantly associated with the variance in processing speed performance in a sample of Chinese college students.
引用
收藏
页码:787 / 789
页数:3
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