Statin use in older people primary prevention on cardiovascular disease: an updated systematic review and meta-analysis

Background: Evidence on statin use for primary prevention of cardiovascular disease (CVD) in older people needs to be extended and updated, aiming to provide further guidance for clinical practice. Methods: PubMed, EMBASE, Cochrane Library and Web of Science were searched for eligible observational studies comparing statin use vs. no-statin use for primary prevention of CVD in older people (age 20% diabetic populations (HR: 0.50, 95% CI: 0.40-0.64), and 50% hypertensive populations (HR: 0.38, 95% CI: 0.16-0.88). Conclusions: Statin use was related to a 46%, 49%, 17%, 21% and 25% risk reduction on all-cause mortality, CVD mortality, CHD/MI, stroke and total CV events in older patients, respectively. The significant association was also addressed in older patients and 75 years old individuals for CVD primary prevention.