Endocrine aspects of reproduction in the ageing female

The natural decline of fertility affects women from the end of the third decade of life and becomes particularly relevant in the fifth. decade. The request of a treatment to achieve pregnancy on behalf of women over 40 years of age is continuously increasing. Unfortunately, assisted reproduction in these subjects gets a lower PR/cycle, a lower cumulative conception rate, a higher abortion rate and lower take-home baby rate in comparison to younger women. The main reason accounting for the worsening of results in mature women is the lower number and worse quality of oocytes obtained by ovarian stimulation, in turn conditioning the number and quality of embryos available for transfer. However, even endometrial. receptivity appears to worsen with age.