Visualization of thermally activated nanocarriers using in situ atomic force microscopy

被引：2
|
作者：
Dong, Mingdong
Howard, Kenneth A.
Oupicky, David
Bisht, Harender
Kjems, Jorgen
Besenbacher, Flemming [1 ]
机构：
[1] Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, DK-8000 Aarhus C, Denmark
[2] Aarhus Univ, Dept Phys & Astron, DK-8000 Aarhus C, Denmark
[3] Aarhus Univ, Dept Mol Biol, DK-8000 Aarhus C, Denmark
[4] Wayne State Univ, Dept Pharmaceut Sci, Detroit, MI USA
来源：
NANOTECHNOLOGY | 2007年 / 18卷 / 18期
关键词：
D O I：
10.1088/0957-4484/18/18/185501
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Thermo-responsive nanocarriers aim to improve the delivery of drugs into target tissue by a process of size-mediated deposition activated by thermal stimuli. The direct imaging of thermally-induced changes in nanocarrier morphology was demonstrated using in situ liquid AFM over a nano-scale and temperature range relevant for clinical approaches. In situ AFM proved to be a unique method for investigating the dynamic conformational changes of individual nanoparticles, promoting its application in the future development of stimuli-responsive nanocarriers.
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页数：5
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