The effects of the dopamine D2 agonist sumanirole on prepulse inhibition in rats

被引：19
|
作者：
Weber, Martin [1 ]
Chang, Wei-Li [1 ]
Breier, Michelle R. [1 ]
Yang, Alex [1 ]
Millan, Mark J.
Swerdlow, Neal R. [1 ]
机构：
[1] UCSD Sch Med, Dept Psychiat, La Jolla, CA 92093 USA
来源：
EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2010年 / 20卷 / 06期
关键词：
Dopamine; D2; receptor; Prepulse inhibition; Schizophrenia; Sumanirole; NUCLEUS-ACCUMBENS; RECEPTOR; D3; PRAMIPEXOLE; ANTAGONISTS; MODELS; S33084;
D O I：
10.1016/j.euroneuro.2010.02.011
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Dopamine agonists reduce prepulse inhibition (PPI) of startle in rats. While it is used to predict antipsychotic efficacy, the specific receptor subtypes mediating this effect of dopamine agonists remain unclear. We characterized the effects of sumanirole, a highly selective 02 agonist, on PPI in rats. Sumanirole decreased PPI at 60-120 ms prepulse intervals, and increased PPI at 10-20 ms intervals. PPI deficits were antagonized by low doses of the preferential D2 antagonist L741626, supporting a D2 mechanism of action. Sumanirole is a valuable tool for parsing the role of dopamine receptor subtypes in the regulation of PPI. (C) 2010 Elsevier B.V. and ECNP. All rights reserved.
引用
收藏
页码：421 / 425
页数：5
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