Coproduction of Tet(X7) Conferring High-Level Tigecycline Resistance, Fosfomycin FosA4, and Colistin Mcr-1.1 in Escherichia coli Strains from Chickens in Egypt

被引：31

作者：

Soliman, Ahmed M. ^{[1
,2
]}

Ramadan, Hazem ^{[3
,4
]}

Zarad, Hoda ^{[5
]}

Sugawara, Yo ^{[6
]}

Yu, Liansheng ^{[6
]}

Sugai, Motoyuki ^{[6
]}

Shimamoto, Toshi ^{[7
]}

Hiott, Lari M. ^{[3
]}

Frye, Jonathan G. ^{[3
]}

Jackson, Charlene R. ^{[3
]}

Shimamoto, Tadashi ^{[7
]}

机构：

[1] Hiroshima Univ, Grad Sch Biosphere Sci, Lab Food Microbiol & Hyg, Higashihiroshima, Japan

[2] Kafrelsheikh Univ, Fac Pharm, Dept Microbiol & Immunol, Kafr Al Sheikh, Egypt

[3] USDA ARS, Bacterial Epidemiol & Antimicrobial Resistance Re, US Natl Poultry Res Ctr, Athens, GA 30613 USA

[4] Mansoura Univ, Fac Vet Med, Hyg & Zoonoses Dept, Mansoura, Egypt

[5] Sidi Ghazy Publ Hosp, Sidi Ghazy City, Kafr El Sheikh, Egypt

[6] Natl Inst Infect Dis, Antimicrobial Resistance Res Ctr, Higashimurayama, Japan

[7] Hiroshima Univ, Grad Sch Integrated Sci Life, Lab Food Microbiol & Hyg, Higashihiroshima, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2021年 / 65卷 / 06期

关键词：

tigecycline resistance; colistin resistance; fosfomycin; Mcr-1.1; FosA4; Tet(X7); Egypt; Escherichia coli; chicken; IDENTIFICATION; TRANSPORT; PLASMIDS; ISOLATE; IRON; GENE;

D O I：

10.1128/AAC.02084-20

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The plasmid-mediated tet(X7) conferring high-level tigecycline resistance was identified in five mcr-1.1-positive Escherichia coli strains (ST10 [n = 3] and ST155 [n = 2]) isolated from chickens in Egypt. Two fosfomycin-resistant fosA4-carrying IncFII plasmids (similar to 79 kb in size) were detected. Transposase ISCR3 (IS91 family) is syntenic with tet(X7) in all isolates, suggesting its role in the mobilization of tet(X7). To our knowledge, this is the first global report of ST4-IncHI2 plasmids cocarrying tet (X7) and mcr-1.1 from chickens.

引用

页数：10