A new and convenient approach to heterotetracyclic benzoxazocines through addition of 1,3-dicarbonyl compounds to quinolinium salts

被引：24
|
作者：
Moghaddam, Firouz Matloubi [1 ]
Mirjafary, Zohreh [1 ]
Saeidian, Hamdollah [1 ,2 ]
Taheri, Salman [1 ]
Khodabakhshi, Mohammad Reza [1 ]
机构：
[1] Sharif Univ Technol, Dept Chem, Lab Organ Synth & Nat Prod, Tehran, Iran
[2] Payame Noor Univ, Dept Chem, Zanjan Branch, Zanjan, Iran
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 20期
关键词：
RING-CLOSING METATHESIS; ANTIINFLAMMATORY AGENTS; NITROGEN-HETEROCYCLES; SELECTIVITY; THIOPHENES; SCAFFOLDS; PROTEIN; DERIVATIVES; EFFICIENT; ALKALOIDS;
D O I：
10.1016/j.tetlet.2010.03.038
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of a series of benzoxazocines has been achieved in good yields by tandem C-alkylation and intramolecular O-alkylation of 1,3-dicarbonyl compounds with quinolinium salts. This is a novel example of the synthesis of eight-membered rings via a tandem process, which provides a method for the synthesis of medium-ring heterocycles. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2704 / 2707
页数：4
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